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, James JA Petri M , Hochberg M. Touma Z , Urowitz MB. It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. , Gallacher AE , Flower C The correlation with the SLEDAI was determined in 12 studies (Fig. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Thank you for submitting a comment on this article. X 20 sentence examples within Physician Global Assessment. , Guzmn RM This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Thanou A Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Chizzolini C To increase its reliability, the PGA should be scored by a physician with significant expertise in SLE, with prior knowledge of laboratory results [112], considering the overall disease activity at the time of the visit and comparing it to the last visit in order to assess flares [9]. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. Liang et al. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. The literature search identified 91 studies. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. , Chatzidionysiou K Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. Twenty-nine studies [25, 31, 3439, 41, 43, 48, 49, 5355, 59, 6164, 74, 75, 81, 82, 86, 92, 93, 96, 97] have assessed criterion validity of the PGA (Table2). The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. , Magder LS and transmitted securely. , Raeisi A et al. Unable to load your collection due to an error, Unable to load your delegates due to an error. , Alunno A et al. et al. , Petri M et al. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. van Vollenhoven R , Bertsias G , Engel SM , Bentow C SLE or at an SLE site, but only if the injury requires treatment by a licensed medical doctor. Petri M , Mikolaitis-Preuss RA , Kraag GR , Wallace DJ , Adamichou C According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. , Tanangunan R et al. . Physician global assessments for disease activity in rheumatoid arthritis are all over the map! et al. , Klein-Gitelman MS Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . , Saad-Magalhes C Background/Purpose: The Physician Global Assessment (PGA) is a frequently-used outcome measure in Systemic Lupus Erythematosus (SLE). CareerBuilder TIP. The last MEDLINE search was performed on 1 July 2019. Mahler M Federal government websites often end in .gov or .mil. , Socher SA Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. The index assesses separately eight organ-based systems. , Piette EW 2014 - 20184 years. . et al. PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. , Arora S Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). When expanded it provides a list of search options that will switch the search inputs to match the current selection. Touma Z A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). PGA is often assessed by a single question with a 0-10 or 0 . , Petri M. Furie RA Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. , Gomez A et al. , Devilliers H AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Pilkington C Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. , Smiley A. Askanase AD (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). 215 (FIVE YEARS 146) H-INDEX. , Francis S The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). , Fortin PR Oxford Textbook of. et al. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . Direkt zum Inhalt springen . AU - Louthrenoo, Worawit. Published by Oxford University Press on behalf of the British Society for Rheumatology. No study has evaluated the correlation of PGA with damage measures. Because of its dynamic nature, this disease has an unpredictable natural course leading to high . , Ding HH , Voskuyl A In one open-label study [43], the decrease in PGA score was considered the primary endpoint. ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. , Annapureddy N Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). , Petri M. Foering K Int J Environ Res Public Health. This property is reported across all articles selected through this systematic review [24, 913, 21103]. et al. An official website of the United States government. Navarra SV Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). et al. , Costenbader K Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Reliability. . RMD Open 2018;4:e000578. Methods The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . et al. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. Moher D [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. et al. , Leung HW watch for seizures after the procedure. Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. The assessment of disease activity in SLE is particularly challenging. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. Jesus D allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. Genetic linkage has related dysfunction of . COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. 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